Christina Applegate Discusses Worsening Multiple Sclerosis Symptoms

Christina Applegate got emotional opening up about her struggle with multiple sclerosis, nearly four years after she was first diagnosed.

“I am defined by it right now,” the actor said during an appearance on Hoda Kotb’s podcast, “Making Space,” which was released on Wednesday.

“I have days where I can’t even walk to the bathroom, so I am defined by it,” Applegate said.

“I’m angry at it still, and there’s a lot of us out there who are newly diagnosed that are not quite ready to accept this reality,” she explained. “I keep thinking that I’m just going to wake up from this nightmare, and it’s just going to be over.”

The “Dead to Me” actor added, “I want to do these things and I can’t, and it feels like I’m getting worse. And that’s disheartening. But then there’s like this voice inside of me that is like, ‘You’ve got to believe in a miracle. You’ve got to believe in another side of this.’”

Applegate went public with her multiple sclerosis diagnosis in 2021. She now co-hosts a podcast about life with MS, called “MeSsy,” alongside actor Jamie-Lynn Sigler.

Sigler, best known for her role on “The Sopranos,” was diagnosed at 20 but didn’t share her condition publicly until 2016.

Sigler, who also appeared on Kotb’s podcast with Applegate, said that living with MS for 23 years has “absolutely shaped” who she is as a person.

“Of course, I would love to not struggle in my body,” she said. “I would love to not have a disability. I would love to be able to participate in my life the way I would choose to, but the way that I look at the world, and the way that I feel about people, I don’t know if it would be the same without this.”